LABORATORY ISOTECHNY

An essential tool in biomedical and pharmaceutical research for its reliability and efficiency

Increased security for total work comfort

Over the past decade, isolation technology has widely established itself in the field of biomedical research for housing laboratory animals (mice, rats, poultry) as well as in the production processes of injectable drugs both in the pharmaceutical industry and in hospitals.

Isolators, more commonly known as “glove boxes,” are sterile mini-environments that allow substances to be handled in a delimited area that is completely secure for the user. Moreover, operations carried out in a sterile manner in an isolator provide absolutely reliable results.

Laborantin qui manipule un isolateur de laboratoire

Why use isolation technology?

Isolation technology is considered the most cost-effective system for maintaining absolute protection of handled pharmaceutical products and to ensure operator safety from hazardous compounds.

Compared to clean rooms, isolators improve product quality, reduce operating costs, are suited to longer production campaigns, and eliminate the possibility of adverse effects on personnel.

Advantages over clean rooms

Isolators guarantee the best microbiological conditions and do not require operators to wear personal protective equipment, thereby providing greater safety. They are fully enclosed, sealed, and pressurised units, meeting the most stringent requirements without the need for Class III or IV absolute containment applications or cytotoxic production. However, there are key parameters to be considered in order to maximise an investment in isolation equipment, in particular the essential features and overall design of the systems.

Better product protection

Better protection of the product against what constitutes the greatest risk of contaminations, namely humans

Better operator protection

Better protection of operators against potentially hazardous compounds

Guarantee of sterility

Considerably higher level of sterility guarantee than that obtained without isolation technology

Lower risks

Lower risks assessed with isolators than with clean rooms when handling very efficient substances

Better classification

Better classification (isolators generally operate in clean rooms with class C GMP), which can generate cost savings

Reduced costs

Reduced costs with respect to the work, clothing and other expenses linked with clean rooms.

Manipulation d'isotechnie de laboratoire - Erlab

How does an isolator work?

When selecting the isolator, approval and inspection of the device are essential to ensure performance with regard to both protection of the sterile environment and certain technical characteristics.

It is crucial to verify the secure closure systems (DPTE© doors). One of the most reliable and simplest methods to test integrity is the pressure drop test. It can be used on all protection systems, including door closures, mouse holes, dampers and gloves. The measurement principle facilitates the detection of leaks in gloves and cuffs.

Additionally, bio-decontamination of all surfaces inside the isolator is crucial to ensure product safety and quality. H2O2 vapour decontamination is a well-established method for deactivating microorganisms inside the isolator. After this decontamination phase, the entire system must be flushed with air to completely remove any remaining hydrogen peroxide vapour from inside the isolator.

I.Box+: An absolute protection

The article “I.Box+ to guarantee absolute protection throughout the manufacturing process” was published in the professional journal SALLESPROPRES.

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Laboratory isolation technology equipments.

Isolators for zootechnics

I.Box zoo

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Isolators for pharmaceutical applications and biomedical research

I.Box+

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